Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation

Ed Laufer, Randall Dahn, Olivia E. Orozco, Chang-Yeol Yeo, Jacqueline Pisenti, Domingos Henrique, Ursula K. Abbott, John F. Fallon and Cliff Tabin
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Ed Laufer: Harvard Medical School
Randall Dahn: University of Wisconsin
Olivia E. Orozco: Harvard Medical School
Chang-Yeol Yeo: Harvard Medical School
Jacqueline Pisenti: University of California, Davis
Domingos Henrique: Imperial Cancer Research Fund
Ursula K. Abbott: University of California, Davis
John F. Fallon: University of Wisconsin
Cliff Tabin: Harvard Medical School

Nature, 1997, vol. 386, issue 6623, 366-373

Abstract: Abstract The apical ectodermal ridge of the vertebrate limb bud lies at the junction of the dorsal and ventral ectoderm and directs patterning of the growing limb. Its formation is directed by the boundary between cells that do and cells that do not express the gene Radical fringe. This is similar to the establishment of the margin cells at the Drosophila wing dorsoventral border by fringe. Radical fringe expression in chick-limb dorsal ectoderm is established in part through repression by Engrailed-1 in the ventral ectoderm.

Date: 1997
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DOI: 10.1038/386366a0

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