Biologically erodable microspheres as potential oral drug delivery systems

Edith Mathiowitz, Jules S. Jacob, Yong S. Jong, Gerardo P. Carino, Donald E. Chickering, Pravin Chaturvedi, Camilla A. Santos, Kavita Vijayaraghavan, Sean Montgomery, Michael Bassett and Craig Morrell
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Edith Mathiowitz: Brown University
Jules S. Jacob: Brown University
Yong S. Jong: Brown University
Gerardo P. Carino: Brown University
Donald E. Chickering: Sulzer Carbomedics
Pravin Chaturvedi: Sulzer Carbomedics
Camilla A. Santos: Brown University
Kavita Vijayaraghavan: Brown University
Sean Montgomery: Brown University
Michael Bassett: Brown University
Craig Morrell: Brown University

Nature, 1997, vol. 386, issue 6623, 410-414

Abstract: Abstract Biologically adhesive delivery systems offer important advantages1–5 over conventional drug delivery systems6. Here we show that engineered polymer microspheres made of biologically erodable polymers, which display strong adhesive interactions with gastrointestinal mucus and cellular linings, can traverse both the mucosal absorptive epithelium and the follicle-associated epithelium covering the lymphoid tissue of Peyer's patches. The polymers maintain contact with intestinal epithelium for extended periods of time and actually penetrate it, through and between cells. Thus, once loaded with compounds of pharmacological interest, the microspheres could be developed as delivery systems to transfer biologically active molecules to the circulation. We show that these microspheres increase the absorption of three model substances of widely different molecular size: dicumarol, insulin and plasmid DNA.

Date: 1997
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DOI: 10.1038/386410a0

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