Transcriptional activation by recruitment

Mark Ptashne () and Alexander Gann ()
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Mark Ptashne: Harvard University
Alexander Gann: Lancaster University

Nature, 1997, vol. 386, issue 6625, 569-577

Abstract: Abstract The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating regions and their targets, and for the role of histones in gene regulation.

Date: 1997
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DOI: 10.1038/386569a0

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