Release of gelatinase A during platelet activation mediates aggregation

Grzegorz Sawicki, Eduardo Salas, Jesus Murat, Helena Miszta-Lane and Marek W. Radomski
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Grzegorz Sawicki: University of Alberta
Eduardo Salas: University of Alberta
Jesus Murat: University of Alberta
Helena Miszta-Lane: University of Alberta
Marek W. Radomski: University of Alberta

Nature, 1997, vol. 386, issue 6625, 616-619

Abstract: Abstract Blood platelets limit blood loss at sites of vascular injury by forming a mechanical plug. They are also involved in thrombosis, atherosclerosis, inflammation and metastasis. Platelet activation is essential for these physiological and pathological reactions and depends upon their adhesion to the vessel wall and attachment to each other in the aggregation process. The two known pathways of aggregation are mediated by the release of endoperoxides/throm-boxane A2 and ADP1–3 which amplify platelet aggregation. Here we report the identification of a new pathway of aggregation which is mediated by the release of a metalloproteinase enzyme, gelatinase A.

Date: 1997
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DOI: 10.1038/386616a0

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