Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling

Hiroshi Akimaru, Yang Chen, Ping Dai, Hou De-Xing, Maki Nonaka, Sarah M. Smolik, Steve Armstrong, Richard H. Goodman and Shunsuke Ishii
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Hiroshi Akimaru: Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN)
Yang Chen: Oregon Health Sciences Unviersity
Ping Dai: Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN)
Hou De-Xing: Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN)
Maki Nonaka: Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN)
Sarah M. Smolik: Oregon Health Sciences Unviersity
Steve Armstrong: Oregon Health Sciences Unviersity
Richard H. Goodman: Oregon Health Sciences Unviersity
Shunsuke Ishii: Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN)

Nature, 1997, vol. 386, issue 6626, 735-738

Abstract: Abstract The transcription factor CBP, originally identified as a coactivator for CREB1,2, enhances transcription mediated by many other transcription factors3–7. Mutations in the human CBP gene are associated with Rubinstein–Taybi syndrome, a haploinsufficiency disorder characterized by abnormal pattern formation8, but the mechanism by which decreased CBP levels affect pattern formation is unclear. The hedgehog (hh) signalling pathway is an important determinant of pattern formation, cubitus interruptus (ci), a component in hh signalling, encodes a transcription factor homologous to the Gli family of proteins9 and is required for induction of the hh-dependent expression of patched (ptc), decapentaplegic (dpp) and wingless (wg)10. Haploinsufficiency for the ci-related transcription factor Gli3 causes phenotypic changes in mice (known as 'extra-toes)11 and humans (Greig's cephalopolysyndactyly syndrome)12 that have similarities to Rubinstein-Taybi syndrome. Here we show that Drosophila CBP (dCBP) functions as a coactivator of Ci, suggesting that the dCBP-Ci interaction may shed light on the contribution of CBP to pattern formation in mammals.

Date: 1997
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DOI: 10.1038/386735a0

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