Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Lelia Alland, Rebecca Muhle, Harry Hou, Jason Potes, Lynda Chin, Nicole Schreiber-Agus and Ronald A. DePinho
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Lelia Alland: Department of Microbiology and Immunology
Rebecca Muhle: Department of Microbiology and Immunology
Harry Hou: Department of Microbiology and Immunology
Jason Potes: Department of Microbiology and Immunology
Lynda Chin: Department of Microbiology and Immunology
Nicole Schreiber-Agus: Department of Microbiology and Immunology
Ronald A. DePinho: Department of Microbiology and Immunology

Nature, 1997, vol. 387, issue 6628, 49-55

Abstract: Abstract Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sln3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.

Date: 1997
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DOI: 10.1038/387049a0

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