Encapsulation of bilayer vesicles by self-assembly

Scott A. Walker, Michael T. Kennedy and Joseph A. Zasadzinski
Additional contact information
Scott A. Walker: University of California
Michael T. Kennedy: University of California
Joseph A. Zasadzinski: University of California

Nature, 1997, vol. 387, issue 6628, 61-64

Abstract: Abstract Vesicles of lipid bilayers have been investigated as drug-delivery vehicles for almost 20 years1-8. The vesicles’ interior space is separated from the surrounding solution because small molecules have only limited permeability through the bilayer. Single-walled (unilamellar) vesicles are made by a variety of non-equilibrium techniques, including mechanical disruption of lamellar phases by sonication or extrusion through filters, or chemical disruption by detergent dialysis or solvent removal5. These techniques do not, however, allow the encapsulation of a specific volume, nor can they be used to encapsulate other vesicles. Here we show that molecular-recognition processes mediated by lipophilic receptors and substrates (here the biotin–streptavidin complex)9 can be used to produce a multicompartmental aggregate of tethered vesicles encapsulated within a large bilayer vesicle. We can these encapsulated aggregates vesosomes. Encapsulation is achieved by unrolling bilayers from cochleate cylinders5,10-12 which are tethered to the aggregate by biotin–streptavidin coupling. These compartmentalized vesosomes could provide vehicles for multicomponent or multifunctional drug delivery2-4,6;in particular, the encapsulating membrane could significantly modify permeation properties, or could be used to enhance the biocompatibility of the system.

Date: 1997
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/387061a0 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:387:y:1997:i:6628:d:10.1038_387061a0

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/387061a0

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().