Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

Tae-Wook Chun, Lucy Carruth, Diana Finzi, Xuefei Shen, Joseph A. DiGiuseppe, Harry Taylor, Monika Hermankova, Karen Chadwick, Joseph Margolick, Thomas C. Quinn, Yen-Hong Kuo, Ronald Brookmeyer, Martha A. Zeiger, Patricia Barditch-Crovo and Robert F. Siliciano
Additional contact information
Tae-Wook Chun: Johns Hopkins University School of Medicine
Lucy Carruth: Johns Hopkins University School of Medicine
Diana Finzi: Johns Hopkins University School of Medicine
Xuefei Shen: Johns Hopkins University School of Medicine
Joseph A. DiGiuseppe: Johns Hopkins University School of Medicine
Harry Taylor: Johns Hopkins University School of Medicine
Monika Hermankova: Johns Hopkins University School of Medicine
Karen Chadwick: Johns Hopkins University School of Hygiene and Public Health
Joseph Margolick: Johns Hopkins University School of Hygiene and Public Health
Thomas C. Quinn: Johns Hopkins University School of Medicine
Yen-Hong Kuo: Johns Hopkins University School of Hygiene and Public Health
Ronald Brookmeyer: Johns Hopkins University School of Hygiene and Public Health
Martha A. Zeiger: Johns Hopkins University School of Medicine
Patricia Barditch-Crovo: Johns Hopkins University School of Medicine
Robert F. Siliciano: Johns Hopkins University School of Medicine

Nature, 1997, vol. 387, issue 6629, 183-188

Abstract: Abstract The capacity of HIV-1 to establish latent infection of CD4+ T cells may allow viral persistence despite immune responses and antiretroviral therapy. Measurements of infectious virus1,2 and viral RNA3,4 in plasma and of infectious virus1, viral DNA5–10 and viral messenger RNA species11–14 in infected cells all suggest that HIV-1 replication continues throughout the course of infection. Uncertainty remains over what fraction of CD4+ T cells are infected and whether there are latent reservoirs for the virus. We show here that during the asymptomatic phase of infection there is an extremely low total body load of latently infected resting CD4+ T cells with replication-competent integrated pro virus (

Date: 1997
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DOI: 10.1038/387183a0

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