The role of RhoA in tissue polarity and Frizzled signalling

David I. Strutt, Ursula Weber and Marek Mlodzik
Additional contact information
David I. Strutt: EMBL
Ursula Weber: EMBL
Marek Mlodzik: EMBL

Nature, 1997, vol. 387, issue 6630, 292-295

Abstract: Abstract The tissue polarity genes of Drosophila are required for correct establishment of planar polarity in epidermal structures1,2, which in the eye is shown in the mirror-image symmetric arrangement of ommatidia relative to the dorsoventral midline. Mutations in the genes frizzled (fz), dishevelled (dsh) and prickle-spiny-legs (pk-sple) result in the loss of this mirror-image symmetry3–5, fz encodes a serpentine receptor-like transmembrane protein required for reception and transmission of a polarity signal5,6. Little else is known of the signalling pathway(s) involved other than that Dsh acts downstream of Fz7. We have identified mutations in the Drosophila homologue of RhoA p21 GTPase, and by analysis of their phenotype show that RhoA is required for the generation of tissue polarity. Genetic interactions indicate a role for RhoA in signalling mediated by Fz and Dsh, and furthermore suggest that JNK/SAPK-like kinases are involved. These data are consistent with a Fz/RhoA signalling cascade analogous to the yeast pheromone signalling pathway8 and that proposed for activation of the serum response factor (SRF) in vertebrate cells9.

Date: 1997
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/387292a0 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:387:y:1997:i:6630:d:10.1038_387292a0

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/387292a0

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().