Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

Kermit L. Carraway, Janet L. Weber, Michelle J. Unger, Jessica Ledesma, Naichen Yu, Martin Gassmann and Cary Lai
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Kermit L. Carraway: Beth Israel Hospital
Janet L. Weber: The Scripps Research Institute
Michelle J. Unger: Beth Israel Hospital
Jessica Ledesma: The Scripps Research Institute
Naichen Yu: The Scripps Research Institute
Martin Gassmann: The Salk Institute
Cary Lai: The Scripps Research Institute

Nature, 1997, vol. 387, issue 6632, 512-516

Abstract: Abstract The neuregulins (NRGs) are a family of multipotent epidermal-growth-factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.

Date: 1997
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DOI: 10.1038/387512a0

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