Time to get excited by GABA

Christopher S. Colwell
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Christopher S. Colwell: Mental Retardation Research Center, University of California at Los Angeles

Nature, 1997, vol. 387, issue 6633, 554-555

Abstract: The neurotransmitter g-aminobutyric acid has long been thought to have an inhibitory effect on neurotransmission. But a new study shows that, in cells of the suprachiasmatic nucleus (SCN), GABA can be excitatory. Moreover, cells of the SCN are responsible for the generation of circadian rhythms in mammals, and GABA seems to act as an excitatory neurotransmitter only during the day.

Date: 1997
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DOI: 10.1038/42362

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