Switching channels makes sense

Anthony P. F. Turner ()
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Anthony P. F. Turner: Institute of BioScience and Technology, Cranfield University

Nature, 1997, vol. 387, issue 6633, 555-557

Abstract: A stable, highly sensitive chemical sensor has been built that operates by switching ion channels in a lipid membrane. The ion channels are formed by two gramicidin molecules: one in the lower layer of the membrane, linked to a gold electrode; and one in the upper layer, tethered to an antibody. When a molecule of the chosen type binds to the antibody and to a second antibody tethered elsewhere, the two gramicidin molecules are pulled apart, the channel is broken, and the conductivity drops.

Date: 1997
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DOI: 10.1038/42365

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