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Hypermutation under stress

Bryn A. Bridges
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Bryn A. Bridges: MRC Cell Mutation Unit, University of Sussex

Nature, 1997, vol. 387, issue 6633, 557-558

Abstract: When microorganisms are starved of nutrients, the rate of mutation of their genomes accelerates. But are these mutations directed towards those genes that might prove effective in rectifying the nutritional deficiency concerned, or are they random? New studies on a commonly used system (mutants of Escherichia coli that cannot use lactose) point to the second possibility.

Date: 1997
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DOI: 10.1038/42370

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