Chiral discrimination using piezoelectric and optical gas sensors

K. Bodenhöfer, A. Hierlemann, J. Seemann, G. Gauglitz, B. Koppenhoefer and W. Gpel ()
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K. Bodenhöfer: Institute of Physical and Theoretical Chemistry, Centre of Interface Analysis and Sensors
A. Hierlemann: *
J. Seemann: Institute of Physical and Theoretical Chemistry, Centre of Interface Analysis and Sensors
G. Gauglitz: Institute of Physical and Theoretical Chemistry, Centre of Interface Analysis and Sensors
B. Koppenhoefer: †Institute of Organic Chemistry, University of Tbingen
W. Gpel: Institute of Physical and Theoretical Chemistry, Centre of Interface Analysis and Sensors

Nature, 1997, vol. 387, issue 6633, 577-580

Abstract: Abstract Odour perception in humans can sometimes discriminate different enantiomers of a chiral compound1,2,3, such as limonene. Chiral discrimination represents one of the greatest challenges in attempts to devise selective and sensitive gas sensors. The importance of such discrimination for pharmacology is clear, as the physiological effect of enantiomers of drugs and other biologically active molecules may differ significantly4. Here we describe two different sensor systems that are capable of recognizing different enantiomers and of qualitatively monitoring the enantiomeric composition of amino-acid derivatives and lactates in the gas phase. One sensor detects changes in mass, owing to binding of the compound being analysed (the ‘analyte’), by thickness shear-mode resonance5,6,7; the other detects changes in the thickness of a surface layer by reflectometric interference spectroscopy8,9,10. Both devices use the two enantiomers of a chiral polymeric receptor, and offer rapid on-line detection of chiral species with high selectivity.

Date: 1997
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DOI: 10.1038/42426

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