Signalling through the lipid products of phosphoinositide-3-OH kinase

Alex Toker () and Lewis C. Cantley ()
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Alex Toker: Boston Biomedical Research Institute
Lewis C. Cantley: Beth Israel Deaconess Medical Center

Nature, 1997, vol. 387, issue 6634, 673-676

Abstract: Abstract When a stimulatory agonist molecule binds at the exterior of the cell membrane, a second messenger transduces the signal to the interior of the cell. Second messengers can be derived from phospholipids in the membrane by the action of the enzymes phospholipase C or phosphoinositide-3-OH kinase (PI(3)K). PI(3)K is a key player in many cellular responses, including the movement of organelle membranes, shape alteration through rearrangement of cytoskeletal actin, transformation and chemotaxis. But how PI(3)K mediates these responses is only now becoming clear.

Date: 1997
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DOI: 10.1038/42648

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