The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

Joseph Torchia, David W. Rose, Juan Inostroza, Yasutomi Kamei, Stefan Westin, Christopher K. Glass and Michael G. Rosenfeld
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Joseph Torchia: *Howard Hughes Medical Institute, University of California
David W. Rose: University of California
Juan Inostroza: *Howard Hughes Medical Institute, University of California
Yasutomi Kamei: *Howard Hughes Medical Institute, University of California
Stefan Westin: Cellular and Molecular Medicine, University of California
Christopher K. Glass: Cellular and Molecular Medicine, University of California
Michael G. Rosenfeld: *Howard Hughes Medical Institute, University of California

Nature, 1997, vol. 387, issue 6634, 677-684

Abstract: Abstract The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the cell as a complex with CBP and is required for transcriptional activity of nuclear receptors and other CBP/p300-dependent transcription factors. The highly related nuclear-receptor co-activator protein NCoA-1 is also specifically required for ligand-dependent activation of genes by nuclear receptors. p/CIP, NCoA-1 and CBP all contain related leucine-rich charged helical interaction motifs that are required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signal-transduction pathways.

Date: 1997
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DOI: 10.1038/42652

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