A peptide antibiotic from human skin

J. Harder, J. Bartels, E Christophers and J.-M. Schröder
Additional contact information
J. Harder: University of Kiel
J. Bartels: University of Kiel
E Christophers: University of Kiel
J.-M. Schröder: University of Kiel

Nature, 1997, vol. 387, issue 6636, 861-861

Abstract: Abstract To avoid opportunistic infections, plants and animals have developed antimicrobial peptides in their epithelia that can form pores in the cytoplasmic membrane of microorganisms1. After contact with microorganisms, vertebrate skin2, trachea and tongue epithelia3 are rich sources of peptide antibiotics1, which may explain the unexpected resistance of these tissues to infection. Here we report that human skin is protected in a similar way by an inducible, transcriptionally regulated, antibiotic peptide, which resembles those in other mammals.

Date: 1997
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DOI: 10.1038/43088

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