Bridging the gap by AAA ATPases

Tony Rowe and William E. Balch
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Tony Rowe: The Scripps Research Institute
William E. Balch: The Scripps Research Institute

Nature, 1997, vol. 388, issue 6637, 20-21

Abstract: Some of the proteins that are involved in membrane fusion also belong to the so-called AAA-type family of ATPases. Many of these ATPases have accessory molecules, which may act as ‘adaptors’ to mediate the binding of the ATPase to a membrane-bound receptor. Now, rat p97 — an AAA-type ATPase — has been found to have an accessory factor called p47. Moreover, it is the p97/p47 complex, rather than p97 alone, that is required for membrane assembly.

Date: 1997
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DOI: 10.1038/40269

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