Mad about SMADs

Jeff Wrans and Tony Pawson
Additional contact information
Jeff Wrans: The Hospital for Sick Children
Tony Pawson: Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Nature, 1997, vol. 388, issue 6637, 28-29

Abstract: Signalling through the transforming growth factor-beta (TGF-beta) requires the so-called Smad proteins, and two papers now show how the Smads work. TGF-beta binds to its receptor, which then activates Smad2 to form a transcriptionally active complex with Smad4. But the crystal structure of Smad4 shows that its carboxy-terminal domain can join up with its amino-terminal domain, to prevent the formation of a complex and, hence, to inhibit TGF-beta- mediated signalling.

Date: 1997
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DOI: 10.1038/40290

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