Inhibition of ICE slows ALS in mice

Robert M. Friedlander, Robert H. Brown, Valeria Gagliardini, Joy Wang and Junying Yuan ()
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Robert M. Friedlander: Neurosurgical Service, Massachusetts General Hospital, Harvard Medical School
Robert H. Brown: Day Neuromuscular Research Laboratory, Massachusetts General Hospital
Valeria Gagliardini: Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School
Joy Wang: Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School
Junying Yuan: Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School

Nature, 1997, vol. 388, issue 6637, 31-31

Abstract: Abstract Amyotrophic lateral sclerosis (ALS) is a progressive age-dependent disease involving degeneration of motor neurons in the brain, brainstem and spinal cord. ALS is universally fatal, with the median survival of patients being five years from diagnosis. In a transgenic mouse model of ALS, we now show that a dominant negative inhibitor of a cell-death gene, the interleukin-1β-converting enzyme (ICE), significantly slows the symptomatic progression of ALS.

Date: 1997
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DOI: 10.1038/40299

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