Spoilt for choice of co-receptors
Paul R. Clapham and
Robin A. Weiss
Additional contact information
Paul R. Clapham: Chester Beatty Laboratories, The Institute of Cancer Research
Robin A. Weiss: Chester Beatty Laboratories, The Institute of Cancer Research
Nature, 1997, vol. 388, issue 6639, 230-231
Abstract:
To infect a cell, the human and simian immunodeficiency viruses have to attach to its membrane, then enter the cell, before subverting the genetic machinery to their own ends. The CD4 membrane receptor has long been known to be essential, but not sufficient, for this process. Eighteen months ago, the first so-called co-receptor was discovered. More have since been identified, and the latest tally for HIV-1 is six. The possibilities thereby opened up for developing drugs that compete with the virus for these binding sites is counterbalanced by the prospect of viral evolution to use alternative co-receptors.
Date: 1997
References: Add references at CitEc
Citations:
Downloads: (external link)
https://www.nature.com/articles/40758 Abstract (text/html)
Access to the full text of the articles in this series is restricted.
Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.
Export reference: BibTeX
RIS (EndNote, ProCite, RefMan)
HTML/Text
Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:388:y:1997:i:6639:d:10.1038_40758
Ordering information: This journal article can be ordered from
https://www.nature.com/
DOI: 10.1038/40758
Access Statistics for this article
Nature is currently edited by Magdalena Skipper
More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().