Spoilt for choice of co-receptors

Paul R. Clapham and Robin A. Weiss
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Paul R. Clapham: Chester Beatty Laboratories, The Institute of Cancer Research
Robin A. Weiss: Chester Beatty Laboratories, The Institute of Cancer Research

Nature, 1997, vol. 388, issue 6639, 230-231

Abstract: To infect a cell, the human and simian immunodeficiency viruses have to attach to its membrane, then enter the cell, before subverting the genetic machinery to their own ends. The CD4 membrane receptor has long been known to be essential, but not sufficient, for this process. Eighteen months ago, the first so-called co-receptor was discovered. More have since been identified, and the latest tally for HIV-1 is six. The possibilities thereby opened up for developing drugs that compete with the virus for these binding sites is counterbalanced by the prospect of viral evolution to use alternative co-receptors.

Date: 1997
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DOI: 10.1038/40758

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