A new SIV co-receptor, STRL33

Ghalib Alkhatib, Fang Liao, Edward A. Berger, Joshua M. Farber () and Keith W. C. Peden
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Ghalib Alkhatib: *Laboratory of Viral Diseases, NIAID, National Institutes of Health
Fang Liao: †Laboratory of Clinical Investigation, NIAID, National Institutes of Health
Edward A. Berger: *Laboratory of Viral Diseases, NIAID, National Institutes of Health
Joshua M. Farber: †Laboratory of Clinical Investigation, NIAID, National Institutes of Health
Keith W. C. Peden: Laboratory of Retrovirus Research, CBER, Food and Drug Administration

Nature, 1997, vol. 388, issue 6639, 238-238

Abstract: Abstract The identification last year of chemokine receptors as fusion co-factors for HIV-11,2,3,4,5,6 has contributed significantly towards understanding HIV transmission and AIDS pathogenesis (see ref. 7 for a review). Because the experimental infection of rhesus macaques with simian immunodeficiency virus (SIV) and the resulting development of an AIDS-like illness is the best animal model for HIV disease in humans8, identifying SIV co-receptors analogous to those used by HIV has obvious importance. We now report that STRL33, a chemokine receptor-like orphan receptor expressed in activated human lymphocytes and acting as a fusion co-factor with envelope glycoproteins (Envs) from HIV-1 strains of diverse tropisms9, is a co-receptor for SIV.

Date: 1997
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DOI: 10.1038/40789

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