X-linked IAP is a direct inhibitor of cell-death proteases

Quinn L. Deveraux, Ryosuke Takahashi, Guy S. Salvesen and John C. Reed ()
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Guy S. Salvesen: The Burnham Institute, Program on Apoptosis and Cell Death Research
John C. Reed: The Burnham Institute, Program on Apoptosis and Cell Death Research

Nature, 1997, vol. 388, issue 6639, 300-304

Abstract: Abstract The inhibitor-of-apoptosis (IAP) family of genes has an evolutionarily conserved role in regulating programmed cell death in animals ranging from insects to humans1,2,3,4,5,6. Ectopic expression of human IAP proteins can suppress cell death induced by a variety of stimuli, but the mechanism of this inhibition was previously unknown. Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. As the caspases are highly conserved throughout the animal kingdom and are the principal effectors of apoptosis7, our findings suggest how IAPs might inhibit cell death, providing evidence for a mechanism of action for these mammalian cell-death suppressors.

Date: 1997
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DOI: 10.1038/40901

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