The difference with prokaryotes
Mary-Jane Gething
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Mary-Jane Gething: University of Melbourne
Nature, 1997, vol. 388, issue 6640, 329-331
Abstract:
In prokaryotes, the polypeptide chains in which proteins are synthesized only tend to fold into their final, operational form when the chain is complete. In eukaryotes, by contrast, individual domains of a single protein can fold sequentially and independently. This striking finding can help to resolve the puzzle of why prokaryotes tend to rely much more heavily on chaperonin- assisted protein folding than do eukaryotes, but the molecular mechanisms underlying the different treatment of nascent polypeptide chains remain to be defined.
Date: 1997
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Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:388:y:1997:i:6640:d:10.1038_40979
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DOI: 10.1038/40979
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