IκB kinase all zipped up

Alain Israë ()
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Alain Israë: Unité de Biologie Molculaire de l'Expression Gnique, UMR 321 CNRS, Institut Pasteur

Nature, 1997, vol. 388, issue 6642, 520-521

Abstract: NF-κB is a transcription factor that has a pivotal place in several pathways by whichsignals are transmitted from the cell membrane to the nucleus. Among other reactions, it is animportant mediator of the inflammatory response. This factor is inhibited by being in acomplex, in the cytoplasm, with a molecule known as IκB, and is activated and goesabout its business in the nucleus when IkB is phosphorylated and then degraded. But what doesthe phosphorylating? The answer turns out to be protein kinase dubbed IKK alpha, and it couldbe a highly appropriate target for drugs aimed at controlling inflammation.

Date: 1997
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DOI: 10.1038/41433

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