Structural biology and phylogenetic estimation

Gavin J. P. Naylor () and Wesley M. Brown
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Gavin J. P. Naylor: Iowa State University
Wesley M. Brown: University of Michigan

Nature, 1997, vol. 388, issue 6642, 527-528

Abstract: Abstract When reconstructing evolutionary trees from DNA sequences, it is often assumed that increasing the amount of sequence will improve the phylogenetic estimate1,2. This is based on the notion that historical ‘signal’ will rise above misleading ‘noise’ as more sequence is gathered. Our analysis of mitochondrial genomes fails to support this assumption, but suggests a way to select objectively for data with maximum ‘signal-to-noise’ potential.

Date: 1997
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DOI: 10.1038/41460

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