The complete genome sequence of the gastric pathogen Helicobacter pylori

Tomb, Jean-F.; White, Owen; Kerlavage, Anthony R.; Clayton, Rebecca A.; Sutton, Granger G.; Fleischmann, Robert D.; Ketchum, Karen A.; Klenk, Hans Peter; Gill, Steven; Dougherty, Brian A.; Nelson, Karen; Quackenbush, John; Zhou, Lixin; Kirkness, Ewen F.; Peterson, Scott; Loftus, Brendan; Richardson, Delwood; Dodson, Robert; Khalak, Hanif G.; Glodek, Anna; McKenney, Keith; Fitzegerald, Lisa M.; Lee, Norman; Adams, Mark D.; Hickey, Erin K.; Berg, Douglas E.; Gocayne, Jeanine D.; Utterback, Teresa R.; Peterson, Jeremy D.; Kelley, Jenny M.; Cotton, Matthew D.; Weidman, Janice M.; Fujii, Claire; Bowman, Cheryl; Watthey, Larry; Wallin, Erik; Hayes, William S.; Borodovsky, Mark; Karp, Peter D.; Smith, Hamilton O.; Fraser, Claire M.; Venter, J. Craig

The complete genome sequence of the gastric pathogen Helicobacter pylori

Jean-F. Tomb (), Owen White, Anthony R. Kerlavage, Rebecca A. Clayton, Granger G. Sutton, Robert D. Fleischmann, Karen A. Ketchum, Hans Peter Klenk, Steven Gill, Brian A. Dougherty, Karen Nelson, John Quackenbush, Lixin Zhou, Ewen F. Kirkness, Scott Peterson, Brendan Loftus, Delwood Richardson, Robert Dodson, Hanif G. Khalak, Anna Glodek, Keith McKenney, Lisa M. Fitzegerald, Norman Lee, Mark D. Adams, Erin K. Hickey, Douglas E. Berg, Jeanine D. Gocayne, Teresa R. Utterback, Jeremy D. Peterson, Jenny M. Kelley, Matthew D. Cotton, Janice M. Weidman, Claire Fujii, Cheryl Bowman, Larry Watthey, Erik Wallin, William S. Hayes, Mark Borodovsky, Peter D. Karp, Hamilton O. Smith, Claire M. Fraser and J. Craig Venter
Additional contact information
Jean-F. Tomb: The Institute for Genomic Research
Owen White: The Institute for Genomic Research
Anthony R. Kerlavage: The Institute for Genomic Research
Rebecca A. Clayton: The Institute for Genomic Research
Granger G. Sutton: The Institute for Genomic Research
Robert D. Fleischmann: The Institute for Genomic Research
Karen A. Ketchum: The Institute for Genomic Research
Hans Peter Klenk: The Institute for Genomic Research
Steven Gill: The Institute for Genomic Research
Brian A. Dougherty: The Institute for Genomic Research
Karen Nelson: The Institute for Genomic Research
John Quackenbush: The Institute for Genomic Research
Lixin Zhou: The Institute for Genomic Research
Ewen F. Kirkness: The Institute for Genomic Research
Scott Peterson: The Institute for Genomic Research
Brendan Loftus: The Institute for Genomic Research
Delwood Richardson: The Institute for Genomic Research
Robert Dodson: The Institute for Genomic Research
Hanif G. Khalak: The Institute for Genomic Research
Anna Glodek: The Institute for Genomic Research
Keith McKenney: The Institute for Genomic Research
Lisa M. Fitzegerald: The Institute for Genomic Research
Norman Lee: The Institute for Genomic Research
Mark D. Adams: The Institute for Genomic Research
Erin K. Hickey: The Institute for Genomic Research
Douglas E. Berg: School of Medicine, Washington University St Louis
Jeanine D. Gocayne: The Institute for Genomic Research
Teresa R. Utterback: The Institute for Genomic Research
Jeremy D. Peterson: The Institute for Genomic Research
Jenny M. Kelley: The Institute for Genomic Research
Matthew D. Cotton: The Institute for Genomic Research
Janice M. Weidman: The Institute for Genomic Research
Claire Fujii: The Institute for Genomic Research
Cheryl Bowman: The Institute for Genomic Research
Larry Watthey: The Institute for Genomic Research
Erik Wallin: Arrhenius Laboratory, Stockholm University
William S. Hayes: School of Biology
Mark Borodovsky: School of Biology
Peter D. Karp: SRI International, Artificial Intelligence Center
Hamilton O. Smith: School of Medicine, Johns Hopkins University
Claire M. Fraser: The Institute for Genomic Research
J. Craig Venter: The Institute for Genomic Research

Nature, 1997, vol. 388, issue 6642, 539-547

Abstract: Abstract Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host–pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.

Date: 1997
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/41483 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:388:y:1997:i:6642:d:10.1038_41483

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/41483

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().