Rab3A is essential for mossy fibre long-term potentiation in the hippocampus

Pablo E. Castillo, Roger Janz, Thomas C. Sdhof, Thanos Tzounopoulos, Robert C. Malenka and Roger A. Nicoll ()
Additional contact information
Pablo E. Castillo: Departments of Cellular and Molecular Pharmacology
Roger Janz: The University of Texas Southwestern Medical Center
Thomas C. Sdhof: The University of Texas Southwestern Medical Center
Thanos Tzounopoulos: Departments of Psychiatry and San Francisco
Robert C. Malenka: Departments of Psychiatry and San Francisco
Roger A. Nicoll: Departments of Cellular and Molecular Pharmacology

Nature, 1997, vol. 388, issue 6642, 590-593

Abstract: Abstract Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting increase in synaptic transmission called long-term potentiation (LTP). It is generally believed that this synaptic plasticity may underlie certain forms of learning and memory. LTP at most synapses involves the activation of the NMDA (N-methyl-d-aspartate) subtype of glutamate receptor, but LTP at hippocampal mossy fibre synapses is independent of NMDA receptors and has a component that is induced and expressed presynaptically1. It appears to be triggered by a rise in presynaptic Ca2+(refs 2, 3), and requires the activation of protein kinase A4,5,6, which leads to an increased release of glutamate3,7,8,9,10. Agreat deal is known about the biochemical steps involved in the vesicular release of transmitter11,12,13, but none of these steps has been directly implicated in long-term synaptic plasticity. Here we show that, although a variety of short-term plasticities are normal, LTP at mossy fibre synapses is abolished in mice lacking the synaptic vesicle protein Rab3A.

Date: 1997
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/41574 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:388:y:1997:i:6642:d:10.1038_41574

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/41574

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().