Fusion induces tumour rejection

Ian Hart and Camilo Colaco
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Ian Hart: United Medical Schools of Guys and St Thomas Hospitals
Camilo Colaco: Camilo Colaco is at Quadrant Healthcare

Nature, 1997, vol. 388, issue 6643, 626-627

Abstract: Tumour cells can be eradicated by the body's own immune system, but this relies on a marker to highlight the tumour cells and make sure that normal, healthy cells are not destroyed. This marker is the major histocompatibility complex, which presents tumour antigen on the surface of antigen-presenting cells (APCs). A new study shows that one group of APCs -- the dendritic cells -- can be made to present tumour antigens by direct fusion with tumour cells.

Date: 1997
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DOI: 10.1038/41662

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