Calcium cages, acid baths and recycling receptors

Michael S. Brown, Joachim Herz and Joseph L. Goldstein
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Michael S. Brown: University of Texas Southwestern Medical Center
Joachim Herz: University of Texas Southwestern Medical Center
Joseph L. Goldstein: University of Texas Southwestern Medical Center

Nature, 1997, vol. 388, issue 6643, 629-630

Abstract: The low-density lipoprotein receptor (LDLR) removes cholesterol-carrying lipoproteins from the blood, and mutations in this protein lead to familial hypercholesterolaemia -- a condition that leads to high cholesterol levels and heart attacks at an early age. We're now a step closer to knowing why these mutations are so damaging thanks to a study of one region of the receptor, mutations in which destabilize the whole protein.

Date: 1997
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DOI: 10.1038/41672

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