Neurodegeneration A silent channel opens its gates

Peter H. Seeburg
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Peter H. Seeburg: Max Planck Institute for Medical Research

Nature, 1997, vol. 388, issue 6644, 716-717

Abstract: Many human neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease are caused by the death of specific populations of nerve cells. Using a strain of mutant mouse known aslurcher-- which has a peculiar gait caused by the loss of neurons in a brain structure that is important for motor coordination -- a new study has shown that cell death is due to a mutation in the δ2 subunit of the glutamate receptor.

Date: 1997
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DOI: 10.1038/41880

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