Silencing and DNA repair connect

Stephen P. Jackson ()
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Stephen P. Jackson: University of Cambridge

Nature, 1997, vol. 388, issue 6645, 829-830

Abstract: In defined regions of the genome of eukaryotic organisms DNA is packaged into a form of chromatin known as heterochromatin, the main feature of which is that the DNA generally cannot be transcribed. In the yeastSaccharomyces cerevisiae, the so-called Sir proteins are associated with this transcriptional silencing, and it now emerges that they are also involved in repairing double-strand breaks in DNA induced by ionizing radiation. This is an unexpected and potentially fruitful connection.

Date: 1997
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DOI: 10.1038/42136

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