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Reversing the kinesin ratchet — a diverting tail

R. A. Cross
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R. A. Cross: Molecular Motors Group, Marie Curie Research Institute

Nature, 1997, vol. 389, issue 6646, 15-16

Abstract: Motor proteins such as kinesin help to haul cellular cargo along microtubules, and they are mechanically programmed to move in one direction only -- towards either the rapidly growing plus ends, or the static minus ends. But what determines the direction of movement? To address this question, a chimaera has been created in which the head of a minus-end kinesin is attached to the tail ofa plus-end kinesin. And the chimaera moves in the opposite direction to the minus-end heads.

Date: 1997
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DOI: 10.1038/37864

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