Killer in search of a motive?

Bruce Clurman () and Mark Groudine ()
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Bruce Clurman: the Fred Hutchinson Cancer Research Center, and the University of Washington School of Medicine
Mark Groudine: the Fred Hutchinson Cancer Research Center, and the University of Washington School of Medicine

Nature, 1997, vol. 389, issue 6647, 122-123

Abstract: The p53 protein is mutated in over 50% of human cancers, and has gained the title 'guardian of the genome' due to its crucial functions in regulating cell growth and death. A hitherto unknown protein, termed p73, has now been discovered and characterized, and it seems to share structural and functional similarity with p53. But more tests need to be done before p73 can be confirmed as a tumour-suppressor gene.

Date: 1997
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DOI: 10.1038/38116

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