Guides to 95 new angles

B. Edward H. Maden
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B. Edward H. Maden: School of Biological Sciences, Life Sciences Building, University of Liverpool

Nature, 1997, vol. 389, issue 6647, 129-130

Abstract: Pseudouridine (y) is a modified form of uridine — the base that occurs only in RNA. But how is it formed? Four new papers now show that formation of y relies on a group of small nucleolar RNAs (snoRNAs), which hydridize with the target RNA sequence, but leave an unpaired window that allows the y synthase to gain access. Surprisingly, this is the same method that is used for ribose methylation of RNA.

Date: 1997
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DOI: 10.1038/38134

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