Caffeine alters plasma adenosine levels

Lydia A. Conlay, Jeffrey A. Conant, Fred deBros and Richard Wurtman
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Lydia A. Conlay: Massachusetts General Hospital and Harvard Medical School
Jeffrey A. Conant: Massachusetts General Hospital and Harvard Medical School
Fred deBros: Massachusetts General Hospital and Harvard Medical School
Richard Wurtman: Laboratory of Neuroendocrine Regulation

Nature, 1997, vol. 389, issue 6647, 136-136

Abstract: Abstract Since the delights of tea were discovered by Emperor Shen Nung in 2737 BC, methylxanthines have been common in the human diet. Today, the methylxanthine caffeineis the most commonly consumed drug in the world1, with actions mediated primarily by adenosine receptor blockade2. We now report that caffeine increases plasma adenosine concentration in a manner that is dose-related, saturable, and mimicked by peripheral adenosine receptor blockade. Opposite effects are seen after caffeine withdrawal, indicative of a receptor-mediated effect.

Date: 1997
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DOI: 10.1038/38160

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