Clues in the p53 murder mystery

Andrew Wyllie
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Andrew Wyllie: the Sir Alastair Currie CRC Laboratories, University of Edinburgh, Western General Hospital

Nature, 1997, vol. 389, issue 6648, 237-238

Abstract: p53 protein is a central player in the process that results in the repair or in the death by apoptosis of potentially cancerous cells. New work unveils several genes that are controlled by p53. It gives a tantalizing view of the way in which cell death may be mediated by p53-induced, death-specifying transcripts, which generate a burst of reactive oxygen species (ROS) on the mitochondrial membrane. In turn, ROS activate the final killing mechanism of apoptosis. Further research will show whether this seductive scheme is a true reflection of what happens in p53-determined cell death.

Date: 1997
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DOI: 10.1038/38405

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