Phospholipase C isozymes selectively couple to specific neurotransmitter receptors

Daesoo Kim, Ki Sun Jun, Seong Beom Lee, Nae-Gyu Kang, Do Sik Min, Young-Hoon Kim, Sung Ho Ryu, Pann-Ghill Suh and Hee-Sup Shin ()
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Seong Beom Lee: Pohang University of Science and Technology, San-31
Nae-Gyu Kang: Pohang University of Science and Technology, San-31
Do Sik Min: Pohang University of Science and Technology, San-31
Young-Hoon Kim: Institute of Neuroscience, Inje University, 633-165
Sung Ho Ryu: Pohang University of Science and Technology, San-31
Pann-Ghill Suh: Pohang University of Science and Technology, San-31
Hee-Sup Shin: Pohang University of Science and Technology, San-31

Nature, 1997, vol. 389, issue 6648, 290-293

Abstract: Abstract A variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase C-β (PLC-β) coupled with guanine-nucleotide-binding G proteins1. There are four isoenzymes of PLC-β, β1–β4, but their functions in vivo are not known. Here we investigate the role of PLC-β1 and PLC-β4 in the brain by generating null mutations in mice: we found that PLCβ1−/− mice developed epilepsy and PLCβ4−/− mice showed ataxia. We determined the molecular basis of these phenotypes and show that PLC-β1 is involved in signal transduction in the cerebral cortex and hippocampus by coupling predominantly to the muscarinic acetylcholine receptor, whereas PLC-β4 works through the metabotropic glutamate receptor in the cerebellum, illustrating how PLC-β isoenzymes are used to generate different functions in the brain.

Date: 1997
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DOI: 10.1038/38508

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