The importance of being selective

John T. Groves ()
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John T. Groves: Princeton University

Nature, 1997, vol. 389, issue 6649, 329-330

Abstract: Hydroxylating enzymes, such as cytochrome P-450, are immensely important biologically — they mediate the selective insertion of oxygen into the C-H bonds of unreactive molecules such as steroids and prostaglandins, creating key intermediates in the synthesis of drugs and hormones. An artificial P-450 has been designed which shows a high level of positional selectivity in modifying its substrate steroid. Moreover, the reaction exhibits true catalytic turnover of the substrate. Both are attributes necessary for an effective artificial enzyme.

Date: 1997
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DOI: 10.1038/38602

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