Anaesthetics set their sites on ion channels

N. P. Franks and W. R. Lieb
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N. P. Franks: the Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine
W. R. Lieb: the Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine

Nature, 1997, vol. 389, issue 6649, 334-335

Abstract: The effects of alcohol and general anaesthetics are obvious to everybody, but where in the brain — and how — do these agents act? By making hybrid GABAA- and glycine-receptor channels, one group has now identified two amino-acid residues that seem to be crucial for this process. Amino-acid substitutions at these positions remove the effects of anaesthetics, but it's not yet possible to tell whether these amino acids represent a direct binding site, or whether they are involved more indirectly.

Date: 1997
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DOI: 10.1038/38614

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