Straight and wiggly affinities

Peter A. Lawrence ()
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Peter A. Lawrence: the MRC Laboratory of Molecular Biology

Nature, 1997, vol. 389, issue 6651, 546-547

Abstract: Insect embryos are constructed in modules, or compartments; in the wing of Drosophila, for instance, there are two — anterior (A) and posterior (P). How cells know which compartment they belong to is thought to be controlled by the activity of the engrailed gene, which determines cell affinities in the two compartments. Surprising new findings suggest, however, that the largest contributor to the affinity difference between the two types of cells is the indirect action of a protein called Hedgehog, signalling from P to A cells across the border between them.

Date: 1997
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DOI: 10.1038/39188

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