Cancer and the knockout mouse

David Wynford-Thomas and David Kipling
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David Wynford-Thomas: University of Wales College of Medicine
David Kipling: University of Wales College of Medicine

Nature, 1997, vol. 389, issue 6651, 551-552

Abstract: Telomeres are found at the end of linear chromosomes. They consist of DNA repeats that are synthesized by an enzyme called telomerase. Telomerase is not expressed in normal somatic cells, and inappropriate expression has been linked to the formation of tumours. To study the function of telomerase, knockout mice have been generated. Interestingly, these mice are both viable and fertile. But later generations of the knockout mice start to develop cancer, dealing a possible blow to anti-telomerase cancer therapies.

Date: 1997
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DOI: 10.1038/39207

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