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Making sense or antisense?

Wolf Reik and Miguel Constancia
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Wolf Reik: the Laboratory of Developmental Genetics and Imprinting, The Babraham Institute
Miguel Constancia: the Laboratory of Developmental Genetics and Imprinting, The Babraham Institute

Nature, 1997, vol. 389, issue 6652, 669-671

Abstract: During development, genes can be expressed from either the maternal or the paternal chromosomes, in a process known as genomic imprinting. Usually, one copy of the gene is not expressed. But how is this expression controlled? A new study shows that the crucial imprinting signal may be carried by differentially methylated genes. Moreover, expression from, say, a maternal gene, may be prevented by the production of an antisense transcript from the corresponding paternal gene.

Date: 1997
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DOI: 10.1038/39461

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