A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

Hervé Groux, Anne O'Garra, Mike Bigler, Matthieu Rouleau, Svetlana Antonenko, Jan E. de Vries and Maria Grazia Roncarolo
Additional contact information
Hervé Groux: DNAX Research Institute of Molecular and Cellular Biology, Inc.
Anne O'Garra: DNAX Research Institute of Molecular and Cellular Biology, Inc.
Mike Bigler: DNAX Research Institute of Molecular and Cellular Biology, Inc.
Matthieu Rouleau: DNAX Research Institute of Molecular and Cellular Biology, Inc.
Svetlana Antonenko: DNAX Research Institute of Molecular and Cellular Biology, Inc.
Jan E. de Vries: Novartis Research Institute
Maria Grazia Roncarolo: University of Torino

Nature, 1997, vol. 389, issue 6652, 737-742

Abstract: Abstract Induction and maintenance of peripheral tolerance are important mechanisms to maintain the balance of the immune system. In addition to the deletion of T cells and their failure to respond in certain circumstances, active suppression mediated by T cells or T-cell factors has been proposed as a mechanism for maintaining peripheral tolerance1. However, the inability to isolate and clone regulatory T cells involved in antigen-specific inhibition of immune responses has made it difficult to understand the mechanisms underlying such active suppression. Here we show that chronic activation of both human and murine CD4+T cells in the presence of interleukin (IL)-10 gives rise to CD4+T-cell clones with low proliferative capacity, producing high levels of IL-10, low levels of IL-2 and no IL-4. These antigen-specific T-cell clones suppress the proliferation of CD4+T cells in response to antigen, and prevent colitis induced in SCID mice by pathogenic CD4+CD45RBhighsplenic T cells. Thus IL-10 drives the generation of a CD4+T-cell subset, designated T regulatory cells 1 (Tr1), which suppresses antigen-specific immune responses and actively downregulates a pathological immune response in vivo .

Date: 1997
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/39614 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:389:y:1997:i:6652:d:10.1038_39614

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/39614

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().