Developmental neurobiology Neurotrophins moving forward

John V. Heymach and Barbara A. Barres
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John V. Heymach: Stanford University School of Medicine
Barbara A. Barres: Stanford University School of Medicine

Nature, 1997, vol. 389, issue 6653, 789-791

Abstract: When neurons innervate their target cells, it's well known that they transmit signalling molecules known as neurotrophins to these cells, in a process known as anterograde transport. For the first time, one group has now shown that retrograde transport can also occur — that is, the same neurotrophins are carried from the target cell to the neuron. These interactions are probably crucial for sculpting the developing brain into its final, functional form.

Date: 1997
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DOI: 10.1038/39743

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