Rhomantic interludes raise blood pressure

A. P. Somlyo
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A. P. Somlyo: the Center for Structural Biology of the University of Virginia

Nature, 1997, vol. 389, issue 6654, 909-911

Abstract: Calcium is a crucial player in the contraction of both smooth and striated muscle. Smooth muscles regulate the size of the lumen of many different vessels including the arteries, airways, and gut, and so their abnormal contraction can cause diseases such as asthma or high blood pressure. A new drug called Y-27632, which specifically inhibits the Rho-associated kinases, renders smooth muscles less sensitive to calcium. Furthermore, this drug is able to reduce high blood pressure in animals. However, its benefits in treating patients with high blood pressure have yet to be elucidated.

Date: 1997
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DOI: 10.1038/40002

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