Chaperoning extended life

Marc Tatar (), Aziz A. Khazaeli and James W. Curtsinger
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Marc Tatar: Evolution and Behavior, University of Minnesota
Aziz A. Khazaeli: Evolution and Behavior, University of Minnesota
James W. Curtsinger: Evolution and Behavior, University of Minnesota

Nature, 1997, vol. 390, issue 6655, 30-30

Abstract: Abstract The capacity to moderate internal and external stress is arguably the central function regulating senescence in whole-animal ageing1,2,3. During ageing, molecular chaperones such as heat-shock proteins are thought to combat stress-related senescent dysfunction4,5. In transgenic Drosophila melanogaster, with varying copy numbers of the gene hsp70 encoding heat-shock protein hsp70, we found that heat-induced expression of hsp70 increased lifespan at normal temperatures. Only a brief, low level of expression was required to obtain a long-term improvement in survival.

Date: 1997
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DOI: 10.1038/36237

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