Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro-o (), Yutaka Matsumura, Hiroki Aizawa, Hiroshi Kawaguchi, Tatsuo Suga, Toshihiro Utsugi, Yoshio Ohyama, Masahiko Kurabayashi, Tadashi Kaname, Eisuke Kume, Hitoshi Iwasaki, Akihiro Iida, Takako Shiraki-Iida, Satoshi Nishikawa, Ryozo Nagai and Yo-ichi Nabeshima ()
Additional contact information
Makoto Kuro-o: National Institute of Neuroscience, NCNP
Yutaka Matsumura: National Institute of Neuroscience, NCNP
Hiroki Aizawa: National Institute of Neuroscience, NCNP
Hiroshi Kawaguchi: Faculty of Medicine, University of Tokyo
Tatsuo Suga: University of Gunma School of Medicine
Toshihiro Utsugi: University of Gunma School of Medicine
Yoshio Ohyama: University of Gunma School of Medicine
Masahiko Kurabayashi: University of Gunma School of Medicine
Tadashi Kaname: Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine
Eisuke Kume: Lead Optimization Research Laboratory, Tanabe Seiyaku Co. Ltd
Hitoshi Iwasaki: Lead Optimization Research Laboratory, Tanabe Seiyaku Co. Ltd
Akihiro Iida: Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd
Takako Shiraki-Iida: National Institute of Neuroscience, NCNP
Satoshi Nishikawa: Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co. Ltd
Ryozo Nagai: University of Gunma School of Medicine
Yo-ichi Nabeshima: National Institute of Neuroscience, NCNP

Nature, 1997, vol. 390, issue 6655, 45-51

Abstract: Abstract A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the β-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

Date: 1997
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DOI: 10.1038/36285

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