Inositol lipid pathways turn turtle

Kath Hinchliffe and Robin Irvine
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Kath Hinchliffe: University of Cambridge
Robin Irvine: University of Cambridge

Nature, 1997, vol. 390, issue 6656, 123-124

Abstract: Phospholipids are important components of cellular signalling pathways and of cell membranes. Two papers in this issue now suggest that phosphatidylinositol-4,5-bisphosphate, a key player in phospholipid synthesis, can be produced by an alternative pathway that involves an enzyme identified nearly a decade ago and a novel lipid substrate. Another newly discovered inositol lipid in this pathway, phosphatidylinositol-3,5-bisphosphate, appears to be involved in the response to osmotic stress in yeast and in mammalian cells.

Date: 1997
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DOI: 10.1038/36458

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