A prion-linked psychiatric disorder

Helena B. Samaia, Jair de Jesus Mari, Homero P. Vallada, Ricardo P. Moura (), Andrew J. G. Simpson () and Ricardo R. Brentania
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Helena B. Samaia: Federal University of São Paulo
Jair de Jesus Mari: Federal University of São Paulo
Homero P. Vallada: University of São Paulo
Ricardo P. Moura: Ludwig Institute for Cancer Research, Rua Professor Antonio Prudente
Andrew J. G. Simpson: Ludwig Institute for Cancer Research, Rua Professor Antonio Prudente
Ricardo R. Brentania: Ludwig Institute for Cancer Research, Rua Professor Antonio Prudente

Nature, 1997, vol. 390, issue 6657, 241-241

Abstract: Abstract The finding that new variant Creutzfeldt-Jakob disease, the recently discovered prion disease thought to be associated with ingestion of bovine offal1, has a prolonged course and can present with psychiatric symptoms2 raised the possibility that hereditary forms of prion disease may also be associated with serious psychiatric disorders. We have sequenced the open reading frame of the prion protein (PrP) gene isolated from 10 patients with a strong family history of psychiatric illness. In one patient we discovered a previously undescribed sequence alteration, N171S, which raises the possibility of a significant extension in the pathologies associated with inherited prion diseases.

Date: 1997
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DOI: 10.1038/36757

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